ANTITRYPANOSOMAL EFFECT OF CRUDE SCORPION VENOM EXTRACT IN TRYPANOSOMA EVANSI INFECTED SWISS ALBINO RATS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 5000
ABSTRACT Despite the control measures against trypanosomiasis over the past few decades, the disease still contributes to the current economic losses and socio-political crises in the sub-Saharan Africa. The recent interest of chemotherapists in aggressive search for novel antitrypanosomal drug agents informed this current investigation to elucidate the acute toxicity and antitrypanosomal efficacy of crude scorpion venom in Trypanosoma evansi infected rats. Eighty (80) medium sized scorpions, brownish in colour with robust metasoma ending in telson were collected from their habitat in Minna metropolis. Venom was collected by electric stimulation of each scorpion telson. Acute toxicity of the venom was established through oral injection of the scorpion venom using graded concentrations (10, 20 and 30 mg/kg body weight) with saline extract of crude venom. The antitrypanosomal bioassay of the venom was performed against established infection in Trypanosoma evansi infected rats. Group 1 was set up as negative control of 0.2ml normal saline /kg/body weight, group 2 as 5mg chloroquine /kg/body weight and group 3 to 5 as 10, 20 and 30 mg/kg/body weight of the scorpion venom. Acute toxicity showed an LD50 extrapolated to be 44.72 mg/kg body weight. Antitrypanosomal bioassay results showed scorpion venom significantly (P˂0.05) reduced the level of parasitemia of the infected rats, with peak activity recorded on the last day of observation, a pattern distinctly different from the positive control and total parasite clearance was recorded on the 5th day in the group treated with 20 and 30 mg/kg body weight venom concentration having 0.00 and 0.00±0. Treatment of infected rats with scorpion venom extract significantly (P˂0.05) ameliorated loss in some body enzymes tested. The crude venom extract also promoted fall in Packed Cell Volume of T. evansi infected rats, promoted body weight loss for the infected untreated group having 71.23±1 against the initial weight of 123.45±1 and elongated the survival time of T. evansi infected rats. Treatment of the infected rats with scorpion venom at 20 and 30 mg/kg body weight significantly restored the liver and spleen to body weight ratio to a level comparable with the normal rats. Findings from this study suggest that scorpion venom posses a potent andpromising source of antitrypanosomal agent.
Related Project Materials
An investigation of the role of government funding in the quality of education in Ijebu North Local Government Area, Ogun State
Background of the Study
Government funding is a critical determinant of the quality of education, influencing infrastructu...
RELATIONSHIP BETWEEN JOB STRESS AND JOB EFFICIENCY AMONG AGRICULTURAL EDUCATION ACADEMIC STAFF IN COLLEGES OF EDUCATION IN NORTH-WEST NIGERIA
Abstract
This study determined the relationship between job stress and job efficiency of agricultural education academic staff in college...
The impact of mobile banking innovations on customer convenience in finance: a case study of Ecobank Nigeria
Background of the Study
Mobile banking has revolutionized the financial landscape by offering unparalleled convenience and...
The Impact of PR Campaigns on Youth Entrepreneurship: A Study of Yola North LGA, Adamawa State
Chapter One: Introduction
1.1 Background of the Study
Youth entrepreneurship is a vital driver...
Investigating the Impact of Sectoral FDI on Economic Diversification in Nigeria
Background of the Study
Economic diversification is vital for reducing over-reliance on specific sectors, particularly in e...
INTERNET AS A RESEARCH TOOLS FOR STUDENTS OF TERTIARY INSTITUTIONS IN NIGERIA
Background of the Study
The internet stated in august 3rd 1962 by J.C.R Lichider of MIT USA as just an ordina...
An Assessment of the Relationship Between Diet and Immune Response to Infectious Diseases in Katsina State
Background of the Study
Nutrition plays a critical role in maintaining a strong immune system, influenc...
THE EFFECT OF SCHOOL CLIMATE AND TEACHER PRODUCTIVITY ON STUDENTS ACADEMIC PERFORMANCE IN SELECTED SECONDARY SCHOOLS
ABSTRACT
This study was carried out on the effect of school climate and teacher productivity on students academic perfor...
AN APPRAISAL OF THE PRIVATISATION AND COMMERCIALISATION LAW AND POLICY IN NIGERIA
ABSTRACT
A global trend has emerged aimed at reducing government’s involvement and attracting private partnership in the economy. T...
The Effect of Global Supply Chain Disruptions on Local Manufacturing: A Study of Guinness Nigeria in Kwara State
Background of the Study
Global supply chain disruptions, such as those caused by pandemics, geopolitical tensions, natur...
